Author

A. R. Fehr

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 6 Organism:mouse· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. K. Johnson· 4 shared A. Roy· 3 shared C. M. Kerr· 3 shared J. J. O'Connor· 3 shared J. J. Pfannenstiel· 2 shared L. S. Voth· 2 shared N. Schwarting· 2 shared P. Gao· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

D. K. Johnson

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

SARS-CoV-2 nsp15 endoribonuclease antagonizes dsRNA-induced antiviral signaling

C. J. Otter, N. Bracci, N. A. Parenti, C. Ye, T. Li Hui, A. Asthana, J. J. Pfannenstiel, N. Jackson, A. R. Fehr, R. H. Silverman, N. A. Cohen, L. Martinez-Sobrido, S. R. Weiss

This study shows that SARS-CoV-2 nsp15 inhibits dsRNA-induced antiviral signaling, which is necessary for viral replication in nasal epithelial cultures.

Proceedings of the National Academy of Sciences · Apr 3, 2024Peer-reviewedMicrobiology

Mutation of a highly conserved isoleucine residue in loop 2 of several ????-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental to infection

C. M. Kerr, J. J. Pfannenstiel, Y. M. Alhammad, J. J. O'Connor, R. Ghimire, R. Shrestha, R. Khattabi, P. Saenjamsai, S. Parthasarathy, P. R. McDonald, P. Gao, D. K. Johnson, S. More, A. Roy, R. Channappanavar, A. R. Fehr

This study shows that mutating a conserved isoleucine in the macrodomain of MERS-CoV and SARS-CoV-2 enhances ADP-ribose binding but reduces viral replication and pathogenesis.

bioRxiv · Jan 3, 2024 · PreprintMicrobiology

PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell and tissue specific manner

C. M. Kerr, S. Parthasarathy, N. Schwarting, J. J. O'Connor, E. Giri, S. More, R. C. Orozco, A. R. Fehr

This paper shows PARP12 inhibits replication of a Mac1 mutant coronavirus in some cell and tissue types but not all, suggesting other PARPs also contribute to antiviral defense.

bioRxiv · Jun 16, 2023 · PreprintMicrobiology

Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screening

A. Roy, Y. M. Alhammad, P. McDonald, D. K. Johnson, J. Zhuo, S. Wazir, D. V. Ferraris, L. Lehtiö, A. Leung, A. R. Fehr

This study identifies 5 compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding through high-throughput screening, with IC50 values under 100 µM.

bioRxiv · Mar 1, 2022Biochemistry

An MHV macrodomain mutant predicted to lack ADP-ribose binding activity is severely attenuated, indicating multiple roles for the macrodomain in coronavirus replication

L. S. Voth, J. J. O'Connor, C. M. Kerr, E. Doerger, N. Schwarting, P. Sperstad, D. K. Johnson, A. R. Fehr

This study shows that a MHV macrodomain mutant with reduced ADP-ribose binding is more attenuated than a mutant with reduced hydrolysis, indicating distinct roles for Mac1 functions in coronavirus replication.

bioRxiv · Mar 30, 2021 · PreprintMicrobiology

The SARS-CoV-2 conserved macrodomain is a mono-ADP-ribosylhydrolase

Y. M. O. Alhammad, M. M. Kashipathy, A. Roy, J.-P. Gagne, P. McDonald, P. Gao, L. Nonfoux, K. P. Battaile, D. K. Johnson, E. D. Holmstrom, G. G. Poirier, S. W. Lovell, A. R. Fehr

This paper identifies SARS-CoV-2's Mac1 as a mono-ADP-ribosylhydrolase, showing it binds and hydrolyzes mono-ADP-ribose, with implications for antiviral therapy.

bioRxiv · May 11, 2020Biochemistry

Coronavirus infection and PARP expression dysregulate the NAD Metabolome: an actionable component of innate immunity

C. D. Heer, D. J. Sanderson, L. S. Voth, Y. M. O. Alhammad, M. S. Schmidt, S. A. J. Trammell, S. Perlman, M. S. Cohen, A. R. Fehr, C. Brenner

This study shows that SARS-CoV-2 infection upregulates MARylating PARPs and NAD synthesis enzymes, and that enhancing NAD levels can reduce viral replication.

bioRxiv · Apr 17, 2020Microbiology