Author

Y. M. O. Alhammad

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Organism:human· 1 Organism:mouse· 1 Assay:structural biology· 1

Frequent Co-Authors

A. R. Fehr· 2 shared A. Roy· 1 shared C. Brenner· 1 shared C. D. Heer· 1 shared D. J. Sanderson· 1 shared D. K. Johnson· 1 shared E. D. Holmstrom· 1 shared G. G. Poirier· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

A. R. Fehr

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Author profile →

2 papers

Recent·Most cited

The SARS-CoV-2 conserved macrodomain is a mono-ADP-ribosylhydrolase

Y. M. O. Alhammad, M. M. Kashipathy, A. Roy, J.-P. Gagne, P. McDonald, P. Gao, L. Nonfoux, K. P. Battaile, D. K. Johnson, E. D. Holmstrom, G. G. Poirier, S. W. Lovell, A. R. Fehr

This paper identifies SARS-CoV-2's Mac1 as a mono-ADP-ribosylhydrolase, showing it binds and hydrolyzes mono-ADP-ribose, with implications for antiviral therapy.

bioRxiv · May 11, 2020Biochemistry

Coronavirus infection and PARP expression dysregulate the NAD Metabolome: an actionable component of innate immunity

C. D. Heer, D. J. Sanderson, L. S. Voth, Y. M. O. Alhammad, M. S. Schmidt, S. A. J. Trammell, S. Perlman, M. S. Cohen, A. R. Fehr, C. Brenner

This study shows that SARS-CoV-2 infection upregulates MARylating PARPs and NAD synthesis enzymes, and that enhancing NAD levels can reduce viral replication.

bioRxiv · Apr 17, 2020Microbiology