Author

E. E. Blythe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

M. Von Zastrow· 2 shared H. Peacock· 1 shared H. Suga· 1 shared K. M. Shokat· 1 shared Q. Hu· 1 shared R. Gao· 1 shared S. A. Dai· 1 shared Z. Zhang· 1 shared

Activity by Year

2020-2024 · peak 1/yr

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8 top collaborators · 28 mutual co-author links

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2 shared papersCell Biology

M. Von Zastrow

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2 papers

Recent·Most cited

β-arrestin-independent endosomal cAMP signaling by a polypeptide hormone GPCR

E. E. Blythe, M. Von Zastrow

This paper shows that VIPR1 can generate endosomal cAMP signals without β-arrestin, revealing β-arrestin's role in shaping the spatiotemporal profile of GPCR signaling.

Nature Chemical Biology · Mar 1, 2024Peer-reviewedCell Biology

State-selective Modulation of Heterotrimeric Gαs Signaling with Macrocyclic Peptides

S. A. Dai, Q. Hu, R. Gao, H. Peacock, E. E. Blythe, Z. Zhang, M. von Zastrow, H. Suga, K. M. Shokat

This study identifies two macrocyclic peptides that selectively modulate active and inactive states of Gs, offering a new approach for developing state-dependent GTPase inhibitors.

bioRxiv · Apr 25, 2020Biochemistry