Author

K. M. Shokat

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

D. M. Peacock· 2 shared Z. Zhang· 2 shared A. Goga· 1 shared B. F. Binkowski· 1 shared C. A. Zimprich· 1 shared C. R. Corona· 1 shared D. R. Wassarman· 1 shared E. E. Blythe· 1 shared

Activity by Year

2017-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCancer Biology

D. M. Peacock

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5 papers

Recent·Most cited

Probing the KRas Switch II Groove by Fluorine NMR Spectroscopy

D. M. Peacock, M. J. S. Kelly, K. M. Shokat

This paper uses 19F NMR spectroscopy with trifluoromethyl ligands to assess nucleotide state occupancy in KRas proteins, identifying selective structures for KRasG12D.

bioRxiv · Jul 15, 2022Cancer Biology

KRAS is vulnerable to reversible switch-II pocket engagement in cells

J. D. Vasta, D. M. Peacock, Q. Zheng, J. A. Walker, Z. Zhang, C. A. Zimprich, M. R. Thomas, M. T. Beck, B. F. Binkowski, C. R. Corona, M. B. Robers, K. M. Shokat

The paper investigates the accessibility of the switch-II pocket in various KRAS mutants using NMR and a cellular engagement assay, showing it is accessible with non-covalent ligands regardless of GDP state.

Nature Chemical Biology · Mar 21, 2022Peer-reviewedCancer Biology

Tissue-Restricted Inhibition of mTOR Using Chemical Genetics

D. R. Wassarman, K. Bankapalli, L. J. Pallanck, K. M. Shokat

This paper develops a chemical-genetic system to selectively inhibit mTOR in specific tissues and validates it in yeast, human cells, and Drosophila.

bioRxiv · Mar 8, 2022Biochemistry

State-selective Modulation of Heterotrimeric Gαs Signaling with Macrocyclic Peptides

S. A. Dai, Q. Hu, R. Gao, H. Peacock, E. E. Blythe, Z. Zhang, M. von Zastrow, H. Suga, K. M. Shokat

This study identifies two macrocyclic peptides that selectively modulate active and inactive states of Gs, offering a new approach for developing state-dependent GTPase inhibitors.

bioRxiv · Apr 25, 2020Biochemistry

Kinome rewiring reveals AURKA is a molecular barrier to the efficacy of PI3K/mTOR-pathway inhibitors in breast cancer

H. J. Donnella, J. T. Webber, R. S. Levin, R. Camarda, O. Momcilovic, N. Bayani, K. N. Shah, J. Korkola, K. M. Shokat, A. Goga, J. Gordan, S. Bandyopadhyay

The paper identifies AURKA as a barrier to PI3K/mTOR inhibitor efficacy in breast cancer by mapping kinome dynamics and showing that AURKA inhibition synergizes with these drugs to induce apoptosis and tumor regression.

bioRxiv · Jun 30, 2017Cancer Biology