Allosteric feedback inhibition of deoxy-D-xylulose-5-phosphate synthase involves monomerization of the active dimer.
X. Di, D. Ortega-Alarcon, R. Kakumanu, E. E. K. Baidoo, A. Velazquez-Campoy, M. RODRIGUEZ-CONCEPCION, J. Perez-Gil
The paper investigates how IPP and DMAPP feedback regulate DXS enzyme activity by inducing monomerization, which affects enzyme stability and pathway flux.
bioRxiv · Jun 12, 2022 · PreprintBiochemistry