Author

M. G. Thompson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:bacteria (other)· 4 Research Focus:cell type annotation· 4 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Assay:metagenomics· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

J. D. Keasling· 6 shared C. J. Petzold· 4 shared J. M. Blake-Hedges· 4 shared A. N. Pearson· 3 shared J. F. Barajas· 3 shared P. Cruz-Morales· 3 shared P. D. Adams· 3 shared A. M. Deutschbauer· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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6 shared papersMicrobiology

J. D. Keasling

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Cellular RNA interacts with MAVS to promote antiviral signaling

N. S. Gokhale, K. Somfleth, M. G. Thompson, R. K. Sam, D. M. Marciniak, L. H. Chu, M. Park, S. Dvorkin, A. Oberst, S. M. Horner, S.-E. Ong, M. Gale, R. Savan

The paper shows that cellular RNA interacts with MAVS to scaffold signaling proteins and promote antiviral signaling by facilitating IRF3 phosphorylation.

bioRxiv · Sep 25, 2023 · PreprintImmunology

Nitrogen metabolism in Pseudomonas putida: functional analysis using random barcode transposon sequencing

M. Schmidt, A. N. Pearson, M. R. Incha, M. G. Thompson, E. E. K. Baidoo, R. Kakumanu, A. Mukhopadhyay, P. M. Shih, A. M. Deutschbauer, L. M. Blank, J. D. Keasling

This study identifies genes and proteins involved in nitrogen metabolism in Pseudomonas putida using transposon sequencing and provides an interactive visualization tool for the data.

bioRxiv · Dec 9, 2021Microbiology

Leveraging host metabolism for bisdemethoxycurcumin production in Pseudomonas putida

M. R. Incha, M. G. Thompson, J. M. Blake-Hedges, Y. Liu, A. N. Pearson, M. Schmidt, J. Gin, C. J. Petzold, A. Deutschbauer, J. D. Keasling

This study identifies bottlenecks in T3PKS product production in Pseudomonas putida and shows that deleting a catabolic enzyme increases bisdemethoxycurcumin yield.

Metabolic Engineering Communications · Jun 1, 2020Peer-reviewedMicrobiology

Characterization of an ECF56-family sigma factor from Streptomyces venezuelae reveals a highly conserved regulome

M. G. Thompson, A. Zargar, P. Cruz-Morales, T. De Rond, S. Chang, A. N. Pearson, G. Goyal, J. F. Barajas, J. M. Blake-Hedges, R. M. Phelan, V. Reyes-Umana, A. C. Hernandez, N. J. Hillson, P. M. Shih, J. D. Keasling

This study characterizes the ECF56-family sigma factor from Streptomyces venezuelae, showing its C-terminal extension is conserved and regulates a highly conserved regulome across Actinobacteria.

bioRxiv · Jan 30, 2020 · PreprintMicrobiology

Fungal seed pathogens of wild chili peppers possess multiple mechanisms to tolerate capsaicinoids

C. A. Adams, K. Zimmerman, K. Fenstermacher, M. G. Thompson, W. Skyrud, S. W. Behie, A. Pringle

This study investigates how fungal seed pathogens of wild chili peppers tolerate capsaicinoids, finding alternative respiratory enzymes and membrane disruption as potential mechanisms.

Applied and Environmental Microbiology · Jan 21, 2020Peer-reviewedMicrobiology

Structural mechanism of regioselectivity in an unusual bacterial acyl-CoA dehydrogenase

J. M. Blake-Hedges, J. Henrique Pereira, P. Cruz-Morales, M. G. Thompson, J. F. Barajas, J. Chen, R. N. Krishna, L. J. G. Chan, D. Nimlos, C. Alonso-Martinez, E. Baidoo, Y. Chen, J. W. Gin, L. Katz, C. J. Petzold, , J. D. Keasling

This paper investigates the structural mechanism of regioselectivity in a bacterial acyl-CoA dehydrogenase, identifying key residues and structural features responsible for its unique substrate specificity.

bioRxiv · Oct 22, 2019Biochemistry

The response of Pseudomonas putida to a complex lignolysate

M.-R. Park, Y. Chen, M. G. Thompson, V. Benites, B. Fong, C. J. Petzold, E. E. K. Baidoo, J. Gladden, P. D. Adams, J. D. Keasling, B. A. Simmons, S. Singer

This paper shows that Pseudomonas putida can grow on lignolysate from sorghum, using aromatic monomers and other unknown factors like amino acids and ionic liquid.

bioRxiv · Sep 10, 2019 · PreprintMicrobiology

Massively parallel fitness profiling reveals multiple novel enzymes in Pseudomonas putida lysine metabolism

M. G. Thompson, J. M. Blake-Hedges, P. Cruz-Morales, J. F. Barajas, S. C. Curran, C. B. Eiben, N. C. Harris, V. T. Benites, J. W. Gin, W. A. Sharpless, F. F. Twigg, W. Skyrud, R. N. Krishna, J. H. Pereira, E. Baidoo, , J. D. Keasling

This paper uses RB-TnSeq to identify novel enzymes in Pseudomonas putida lysine metabolism, revealing new biochemical pathways and functions for DUF1338 proteins.

bioRxiv · Mar 18, 2019Microbiology