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Foamy microglia link oxylipins to disease progression in multiple sclerosis

The paper identifies foamy microglia as contributors to disease progression in secondary progressive MS, linking oxylipins to lesion expansion and proposing monoacylglycerol lipase as a therapeutic target.

Endothelial cannabinoid CB1 receptor deficiency reduces arterial inflammation and lipid uptake in response to atheroprone shear stress

This paper shows that blocking endothelial CB1 receptors reduces arterial inflammation and lipid uptake under atheroprone shear stress, suggesting potential therapeutic benefits for atherosclerosis.

Boosting pro-vitamin A content and bioaccessibility in leaves by combining engineered biosynthesis and storage pathways with high-light treatments

This paper combines engineered biosynthesis and storage pathways with high-light treatments to significantly boost pro-vitamin A content and bioaccessibility in leafy vegetables.

Allosteric feedback inhibition of deoxy-D-xylulose-5-phosphate synthase involves monomerization of the active dimer.

The paper investigates how IPP and DMAPP feedback regulate DXS enzyme activity by inducing monomerization, which affects enzyme stability and pathway flux.

Spatiotemporally Mapping Thermodynamics of Lysosomes and Mitochondria using Cascade Organelle-Targeting Upconversion Nanoparticles

This paper develops temperature-sensitive nanothermometry probes to measure spatiotemporal thermodynamics of lysosomes and mitochondria in living cells, revealing distinct thermal responses to metabolic perturbations.

Clinical Strains of Pseudomonas aeruginosa secret LasB protease to induce hemorrhagic diffused alveolar damage and acute lung injury in mice

This study shows that Pseudomonas aeruginosa induces acute lung injury in mice through its LasB protease, causing hemorrhagic diffuse alveolar damage and hyaline membranes.

Quantitatively Monitoring in situ Mitochondrial Thermal Dynamics by Upconversion Nanoparticles

This study develops upconversion nanoparticles to monitor mitochondrial temperature dynamics in living cells and shows distinct thermal responses to various stimuli.

Glycopeptidomics Analysis of a Cell Line Model Revealing Pathogenesis and Potential Marker Molecules for the Early Diagnosis of Gastric MALT Lymphoma

The paper uses glycopeptidomics to analyze host cell lines and identify specific glycopeptides associated with gastric MALT lymphoma, offering potential markers for early diagnosis.