Author

S. A. Clayton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. R. Clark· 2 shared E. E. Pistilli· 2 shared J. D. O'Neil· 2 shared K. K. Daley· 2 shared L. E. Rentz· 2 shared M. Whetsell· 2 shared O. O. Bolimowska· 2 shared A. D. Mizener· 1 shared

Activity by Year

2023-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersImmunology

A. R. Clark

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Preclinical Multi-Omic Assessment of Pioglitazone in Skeletal Muscles of Mice Implanted with Human HER2/neu Overexpressing Breast Cancer Xenografts

S. A. Clayton, A. D. Mizener, M. Whetsell, L. E. Rentz, E. M. Meadows, W. J. Geldenhuys, E. E. Pistilli

This paper evaluates pioglitazone's effects on muscle fatigue and multi-omic profiles in breast cancer xenograft mice, finding partial restoration of lipid and mitochondrial transcriptomic dysregulation.

bioRxiv · Apr 15, 2024Cancer Biology

The glucocorticoid dexamethasone inhibits HIF-1alpha stabilisation and metabolic reprogramming in lipopolysaccharide-stimulated primary macrophages.

S. A. Clayton, C. Lockwood, J. D. O'Neil, K. K. Daley, S. Hain, D. Abdelmottaleb, O. O. Bolimowska, D. A. Tennant, A. R. Clark

This study shows dexamethasone inhibits HIF-1α stabilization and reduces GLUT1 expression in lipopolysaccharide-stimulated macrophages, impairing glucose uptake and metabolic reprogramming.

bioRxiv · Sep 20, 2023Immunology

Sexual Dimorphism of Skeletal Muscle in a Mouse Model of Breast Cancer: A Functional and Molecular Analysis

L. E. Rentz, M. Whetsell, S. A. Clayton, A. D. Mizner, I. Holaskova, M. G. Chapa, E. H. Hoblitzell, T. D. Eubank, E. E. Pistilli

This study examines sexual dimorphism in skeletal muscle function and molecular composition in a mouse model of breast cancer, finding sex-specific transcriptome and contractile property differences.

bioRxiv · Jun 7, 2023Cancer Biology

The glucocorticoid dexamethasone impairs the expression of anti-viral mediators in activated macrophages by inhibiting both expression and function of interferon beta.

J. D. O'Neil, O. O. Bolimowska, S. A. Clayton, T. Tang, K. K. Daley, S. Lara-Reyna, J. Warner, C. S. Martin, R. Y. Mahida, R. S. Hardy, S. Arthur, A. R. Clark

This study shows dexamethasone inhibits antiviral gene expression in macrophages by suppressing IFNβ expression and downstream interferon-regulated genes.

bioRxiv · May 3, 2023 · PreprintImmunology