Author

E. E. Thornton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. Pearson· 3 shared F. Powrie· 3 shared Y. Gu· 3 shared A. Janney· 2 shared C. Heuberger· 2 shared M. Friedrich· 2 shared N. Ilott· 2 shared A. Bertocchi· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersImmunology

C. Pearson

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3 papers

Recent·Most cited

MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T cell responses

C. Heuberger, A. Janney, N. Ilott, A. Bertocchi, S. Pott, Y. Gu, M. Pohin, M. Friedrich, E. Mann, C. Pearson, F. Powrie, J. Pott, E. E. Thornton, K. J. Maloy

This study shows that intestinal epithelial cells expressing MHC II modulate CD4 T cell responses during intestinal inflammation, dampening pro-inflammatory effector Th cells.

bioRxiv · Jan 23, 2023Immunology

A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice

C.-P. Hackstein, D. Costigan, L. Drexhage, C. Pearson, S. Bullers, N. Ilott, H. D. Akther, Y. Gu, M. E. B. FitzPatrick, O. J. Harrison, L. C. Garner, E. H. Mann, S. Pandey, M. Friedrich, N. M. Provine, , E. E. Thornton

The paper identifies a conserved population of MHC-II restricted, innate-like T cells in the gut of humans and mice that react to commensals and are implicated in colitis.

bioRxiv · Sep 26, 2022 · PreprintImmunology

Intestinal lamina propria supports acquired eTreg suppressor function

Y. Gu, R. Bartolome-Casado, C. Xu, A. Janney, C. Heuberger, C. Pearson, S. Teichmann, E. E. Thornton, F. Powrie

This study identifies spatially compartmentalized Treg subsets in the gut, showing that lamina propria supports acquired eTreg suppressor function through specific interactions with IL-1β+ macrophages and ILC2.

bioRxiv · Aug 26, 2022 · PreprintImmunology