E. Foley

Vibrio cholerae Arrests Intestinal Epithelial Proliferation through T6SS-dependent Activation of the Bone Morphogenetic Protein Pathway.

This study shows Vibrio cholerae inhibits intestinal epithelial repair by activating the BMP pathway in progenitors, both in Drosophila and zebrafish models.

SINGLE CELL RESOLUTION OF THE ADULT ZEBRAFISH INTESTINE UNDER CONVENTIONAL CONDITIONS, AND IN RESPONSE TO AN ACUTE VIBRIO CHOLERAE INFECTION.

This study uses single-cell transcriptomics to analyze adult zebrafish intestines under conventional conditions and after Vibrio cholerae infection, revealing immune responses and similarities to mammalian gut.

Relish/NF-kB acts in intestinal stem cells to promote epithelial repair in Drosophila

This study shows that NF-kB in intestinal stem cells is crucial for epithelial repair in Drosophila, as its loss impairs tissue regeneration and increases mortality.

Immune Regulation of Intestinal Stem Cell Proliferation and Differentiation in Drosophila.

This study shows that immune signaling in Drosophila intestinal stem cells is critical for maintaining epithelial homeostasis, with impaired immunity leading to reduced stem cell numbers and defective differentiation.

Differential effects of commensal bacteria on progenitor cell adhesion, division symmetry and tumorigenesis in the Drosophila intestine.

This study shows that Lactobacillus brevis affects stem cell division symmetry and tumorigenesis in Drosophila intestine by altering integrin expression and distribution.

Glucose extends lifespan through enhanced intestinal barrier integrity in Drosophila

This study shows glucose-enriched diet extends Drosophila lifespan by improving intestinal barrier integrity, independent of caloric restriction or insulin signaling.

Complex symbiont-pathogen interactions inhibit intestinal repair

This study shows that Vibrio cholerae inhibits intestinal epithelial repair in Drosophila by interacting with symbiotic bacteria, highlighting the role of the type six secretion system in pathogenesis.

The Immune Deficiency Pathway Regulates Metabolic Homeostasis in Drosophila.

This study shows that the IMD pathway in Drosophila affects metabolic homeostasis, with mutations leading to metabolic dysregulation and altered infection responses.

Commensal-Pathogen Competition Impacts Host Viability

This study shows that the T6SS of V. cholerae promotes pathogenesis by interacting with host commensals, as demonstrated in a Drosophila model.

Constitutive Immune Activity Promotes Tumorigenesis in Drosophila Intestinal Progenitor Cells.

This study shows that continuous immune activity in Drosophila intestinal progenitor cells disrupts homeostasis and promotes tumor formation.