E. G. Romanowski

Intra-ocular Predation of Fluoroquinolone-Resistant Pseudomonas aeruginosa and Serratia marcescens by Predatory Bacteria

This study evaluates the ability of predatory bacteria to limit intraocular growth of resistant Gram-negative bacteria in a rabbit model, finding that active predation, not antimicrobial effects, is responsible for inhibiting Pseudomonas aeruginosa.

Cefiderocol: A new and effective topical monotherapy treatment for experimental extensively-drug resistant Pseudomonas aeruginosa keratitis

This study tests cefiderocol as a topical treatment for XDR Pseudomonas aeruginosa keratitis, showing it is effective in vitro and in vivo against an XDR isolate.

Rise in frequency of lasR mutant Pseudomonas aeruginosa among keratitis isolates between 1993 and 2021

The paper tracks the rise in lasR mutations in Pseudomonas aeruginosa keratitis isolates from 1993 to 2021, showing increased frequency and association with worse clinical outcomes.

Predatory Bacteria can Reduce Pseudomonas aeruginosa Induced Corneal Perforation and Proliferation in a Rabbit Keratitis Model

IgaA protein, GumB, has a global impact on the transcriptome and surface proteome of Serratia marcescens

This study shows that the GumB protein regulates the Rcs stress response system in S. marcescens, affecting its transcriptome and surface proteome, which impacts virulence factors.

Bacterial keratitis: similar bacterial and clinical outcomes in female versus male New Zealand White rabbits infected with Serratia marcescens

This study finds no significant difference in bacterial burden or corneal scores between male and female rabbits infected with Serratia marcescens, suggesting mixed-sex groups can be used in bacterial keratitis research.

The Rcs stress response system modulates Serratia marcescens induced inflammation and bacterial proliferation in a rabbit keratitis model