N. A. Stella

Intra-ocular Predation of Fluoroquinolone-Resistant Pseudomonas aeruginosa and Serratia marcescens by Predatory Bacteria

This study evaluates the ability of predatory bacteria to limit intraocular growth of resistant Gram-negative bacteria in a rabbit model, finding that active predation, not antimicrobial effects, is responsible for inhibiting Pseudomonas aeruginosa.

Rise in frequency of lasR mutant Pseudomonas aeruginosa among keratitis isolates between 1993 and 2021

The paper tracks the rise in lasR mutations in Pseudomonas aeruginosa keratitis isolates from 1993 to 2021, showing increased frequency and association with worse clinical outcomes.

Predatory Bacteria can Reduce Pseudomonas aeruginosa Induced Corneal Perforation and Proliferation in a Rabbit Keratitis Model

The short chain fatty acid propionic acid activates the Rcs stress response system partially through inhibition of D-alanine racemase

The study identifies propionic acid as an activator of the Rcs stress response in Serratia marcescens, showing it inhibits D-alanine racemase rather than affecting intracellular pH.

IgaA protein, GumB, has a global impact on the transcriptome and surface proteome of Serratia marcescens

This study shows that the GumB protein regulates the Rcs stress response system in S. marcescens, affecting its transcriptome and surface proteome, which impacts virulence factors.

Bacterial keratitis: similar bacterial and clinical outcomes in female versus male New Zealand White rabbits infected with Serratia marcescens

This study finds no significant difference in bacterial burden or corneal scores between male and female rabbits infected with Serratia marcescens, suggesting mixed-sex groups can be used in bacterial keratitis research.

The Rcs stress response system modulates Serratia marcescens induced inflammation and bacterial proliferation in a rabbit keratitis model

Generation of Xylose-inducible promoter tools for Pseudomonas species and their use in implicating a role for the Type II secretion system protein XcpQ in inhibition of corneal epithelial wound closure

This paper develops a xylose-inducible promoter system for Pseudomonas species and uses it to show XcpQ's role in inhibiting corneal wound closure.