E. G. Vides

A Feed-forward Pathway Drives LRRK2 kinase Membrane Recruitment and Activation

This study identifies two distinct binding sites on LRRK2 that mediate its membrane recruitment and activation through Rab GTPase interactions, revealing a feed-forward pathway for kinase activity regulation.

LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade

This study identifies LRRK2-phosphorylated Rab10 as a key factor in sequestering Myosin Va and RILPL2, blocking ciliogenesis in RPE cells.