A. Adhikari

Genome-guided, field-deployable loop-mediated isothermal amplification (LAMP) assay for specific detection of Dickeya dadantii

This paper develops a field-deployable LAMP assay for specific detection of Dickeya dadantii in plant materials, achieving high sensitivity and specificity with no false positives or negatives.

The Natural Products Discovery Center: Release of the First 8490 Sequenced Strains for Exploring Actinobacteria Biosynthetic Diversity

The paper introduces the Natural Products Discovery Center, releasing 8490 sequenced Actinobacteria strains and highlighting their taxonomic and biosynthetic diversity.

Localization of PPM1H phosphatase tunes Parkinsons disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesis

This paper shows that PPM1H phosphatase localization affects its ability to dephosphorylate Rab GTPases, influencing ciliogenesis and membrane trafficking.

Extraction and characterization of cellulose from invasive weeds from central Nepal: A potential prospect of environmental management.

This study extracts and characterizes cellulose from invasive weeds in Nepal, showing it can be used as a sustainable alternative to plastics and textiles.

A Feed-forward Pathway Drives LRRK2 kinase Membrane Recruitment and Activation

This study identifies two distinct binding sites on LRRK2 that mediate its membrane recruitment and activation through Rab GTPase interactions, revealing a feed-forward pathway for kinase activity regulation.

Longitudinal characterisation of phagocytic and neutralisation functions of anti-Spike antibodies in plasma of patients after SARS-CoV-2 infection.

This study shows that phagocytic and neutralisation functions of anti-Spike antibodies persist in SARS-CoV-2 convalescents despite declining antibody titers, with improved antibody affinity correlating with maintained effector functions.

Insulin-like growth factor-2 does not improve behavioral deficits in mouse and rat models of Angelman Syndrome

This study tests IGF-2's ability to improve behavioral deficits in AS mouse and rat models but finds limited and non-enduring effects.

Essential Loop Dynamics Modulates Catalytic Activity in α-Chymotrypsin

This study investigates how essential loop dynamics in alpha-chymotrypsin affect its catalytic activity using optical spectroscopy and molecular dynamics simulations.

A Combined Spectroscopic and Molecular Modeling Study on Structure-Function-Dynamics under Chemical Modification: Alpha-Chymotrypsin with Formalin Preservative

This study examines how formalin modifies alpha-chymotrypsin's structure and function, showing reduced catalytic activity and altered substrate binding due to cross-linking.

Invasive grass litter suppresses native species and promotes disease

This study shows invasive grass litter suppresses native plants and promotes disease in a greenhouse experiment with Microstegium vimineum and Elymus virginicus.

Ageing impairs the airway epithelium defence response to SARS-CoV-2

This study investigates age-related differences in the nasal epithelium's response to SARS-CoV-2, finding that older adults have impaired host defense and lower viral load due to reduced host machinery expression.

Redox Nanomedicine Cures Chronic Kidney Disease (CKD) by Mitochondrial Reconditioning

This study demonstrates that a redox nanomedicine, C-Mn3O4 NPs, treats CKD by restoring mitochondrial function and redox balance in animal models.

Redox Buffering Capacity of Nanomaterials as an Index of ROS-based Therapeutics and Toxicity: A Preclinical Animal Study

This study evaluates the redox buffering capacity of nanomaterials to assess their therapeutic potential and toxicity in a preclinical animal model.

Development of Tribo-Electroceutical Fabrics for Potential Application in Self-sanitizing Personal Protective Equipment (PPE)

This paper develops tribo-electroceutical fabrics that generate hypochlorite ions to sanitize PPE surfaces, reducing microbial infection risk.

Nanoceutical Fabric Prevents COVID-19 Spread through Expelled Respiratory Droplets: A Combined Computational, Spectroscopic and Anti-microbial Study

The paper develops a nanoceutical cotton fabric with zinc oxide nanoflowers to prevent COVID-19 spread through respiratory droplets by trapping and denaturing SARS-CoV-2 spike proteins.

A Nanoceutical Agent for Chemoprevention of Bilirubin Encephalopathy

This paper reports on the development and testing of citrate-functionalized Mn3O4 nanoparticles for the prevention of bilirubin encephalopathy in a mouse model of neonatal hyperbilirubinemia.

Exposure to Traffic-Related Air Pollution is Associated with Greater Bacterial Diversity in the Lower Respiratory Tract of Children

This study finds that higher traffic-related air pollution exposure in children is linked to increased bacterial diversity in lower respiratory tract samples, independent of asthma status.

CONCENTRATION OF THIOUREA IS EFFECTIVE IN BREAKING THE DORMANCY OF POTATO VARIETIES.

This paper tests Thiourea concentrations on potato dormancy breaking and sprouting, finding 1% effective for Desiree and 3% for Cardinal.

Incorporation of a Biocompatible Nanozyme in Cellular Antioxidant Enzyme Cascade Reverses Huntington's Like Disorder in Preclinical Model

This paper demonstrates that a biocompatible nanozyme can reverse Huntington's-like disorder in a preclinical model by mimicking glutathione peroxidase and integrating into the cellular antioxidant cascade.

Emerging fungal pathogen on an invasive grass differentially affects native species

The paper examines how a fungal pathogen affects three native grass species and how competition with an invasive grass influences their biomass.

Potential Impact of Climate Change on One-Horned Rhinoceros (Rhinoceros unicornis) in Nepal

This study uses species distribution modeling to predict climate change impacts on the suitable habitat of One-Horned Rhinoceros in Nepal under different greenhouse gas emission scenarios.

Myosin motor domains carrying mutations implicated in early or late onset Hypertrophic Cardiomyopathy have similar properties

The paper analyzes myosin motor domain mutations in Hypertrophic Cardiomyopathy to compare early and late onset mutations, finding no clear functional differences but identifying distinct changes from DCM mutations.