Author

J. L. Shumate

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

S. R. Pfeffer· 2 shared A. Adhikari· 1 shared A. Lu· 1 shared C. Limouse· 1 shared C. Y. Chiang· 1 shared D. R. Alessi· 1 shared E. G. Vides· 1 shared E. Purlyte· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

S. R. Pfeffer

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2 papers

Recent·Most cited

A Feed-forward Pathway Drives LRRK2 kinase Membrane Recruitment and Activation

E. G. Vides, A. Adhikari, C. Y. Chiang, P. Lis, E. Purlyte, C. Limouse, J. L. Shumate, E. S. Lasso, H. S. Dhekne, D. R. Alessi, S. R. Pfeffer

This study identifies two distinct binding sites on LRRK2 that mediate its membrane recruitment and activation through Rab GTPase interactions, revealing a feed-forward pathway for kinase activity regulation.

bioRxiv · Apr 25, 2022Biochemistry

Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins

P. Saha, J. L. Shumate, J. G. Caldwell, N. Elghobashi-Meinhardt, A. Lu, L. Zhang, N. Olsson, J. E. Elias, S. R. Pfeffer

The paper investigates the role of inter-domain dynamics in cholesterol transport by NPC1 and NPC1L1 proteins, showing that domain movement is essential and that Ezetimibe inhibits NPC1L1 by binding to multiple domains.

bioRxiv · Mar 26, 2020Biochemistry