A Feed-forward Pathway Drives LRRK2 kinase Membrane Recruitment and Activation
E. G. Vides, A. Adhikari, C. Y. Chiang, P. Lis, E. Purlyte, C. Limouse, J. L. Shumate, E. S. Lasso, H. S. Dhekne, D. R. Alessi, S. R. Pfeffer
This study identifies two distinct binding sites on LRRK2 that mediate its membrane recruitment and activation through Rab GTPase interactions, revealing a feed-forward pathway for kinase activity regulation.
bioRxiv · Apr 25, 2022Biochemistry