Illumination of the complement receptors C3aR and C5aR signaling by anaphylatoxins
Y. Wang, Y. Zhuang, E. H. Xu, W. Liu, Y. Xu, Q. Yuan, X. He, P. Luo, W. Fan, J. Zhu, X. Zhang, X. Cheng, Y. Jiang
This study reports the structures of C3a-bound C3aR and C5a-bound C5aR1, revealing their ligand recognition and activation mechanisms.
bioRxiv · Jan 18, 2023 · PreprintBiochemistry