Author

E. J. Geddes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:bacteria (other)· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1 Assay:multiome· 1 Assay:proteomics· 1

Frequent Co-Authors

A. K. Vasan· 1 shared A. P. Heuck· 1 shared A. Prasanna· 1 shared E. Tajkhorshid· 1 shared H. Guo· 1 shared N. Haloi· 1 shared P. J. Hergenrother· 1 shared P.-C. Wen· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiophysics

A. K. Vasan

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2 papers

Recent·Most cited

Cell-based assay to determine Type 3 Secretion System translocon assembly in Pseudomonas aeruginosa using split luciferase

H. Guo, E. J. Geddes, T. J. Opperman, A. P. Heuck

The paper describes a cell-based assay using split luciferase to detect T3SS translocon assembly in Pseudomonas aeruginosa, showing high signal/noise ratio and robustness for inhibitor screening.

bioRxiv · Jun 22, 2023 · PreprintMicrobiology

Rationalizing generation of broad spectrum antibiotics with the addition of a primary amine

N. Haloi, A. K. Vasan, E. J. Geddes, A. Prasanna, P.-C. Wen, W. W. Metcalf, P. J. Hergenrother, E. Tajkhorshid

This study uses molecular dynamics simulations and experimental validation to show that adding a primary amine to antibiotics enhances their permeation through the outer membrane of Gram-negative bacteria by aligning dipole moments and forming electrostatic interactions.

bioRxiv · Aug 10, 2021Biophysics