Author

P. J. Hergenrother

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:differential expression· 2 Organism:E. coli· 2 Research Focus:host-pathogen & immune response· 2 Approach:mechanistic / dynamical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. K. Vasan· 2 shared E. Tajkhorshid· 2 shared N. Haloi· 2 shared P.-C. Wen· 2 shared W. W. Metcalf· 2 shared A. Baum· 1 shared A. Das Gupta· 1 shared A. Garcia-Sastre· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiophysics

A. K. Vasan

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Re-education of myeloid immune cells to reduce regulatory T cell expansion and impede breast cancer progression

H. E. V. Gamage, S. H. Shahoei, S. T. Albright, Y. Wang, A. J. Smith, R. Farmer, E. C. Fink, E. Jacquin, E. Weisser, R. O. Bautista, M. A. Henn, C. P. Schane, A. T. Nelczyk, L. Ma, A. Das Gupta, , E. R. Nelson

This paper shows that NR0B2 in myeloid cells reduces Treg expansion and tumor growth by modulating the NLRP3 inflammasome, with small molecule agonists improving ICB efficacy in breast cancer.

bioRxiv · Aug 14, 2023 · PreprintCancer Biology

Investigation of gating in outer membrane porins provides new perspectives on antibiotic resistance mechanisms

A. K. Vasan, N. Haloi, R. J. Ulrich, M. E. Metcalf, P.-C. Wen, W. W. Metcalf, P. J. Hergenrother, D. Shukla, E. Tajkhorshid

This study uses molecular dynamics simulations and experiments to show that dynamic gating of E. coli outer membrane porin OmpF, mediated by conserved acidic residues, regulates antibiotic permeability and contributes to antibiotic resistance.

bioRxiv · Sep 9, 2021 · PreprintBiophysics

Rationalizing generation of broad spectrum antibiotics with the addition of a primary amine

N. Haloi, A. K. Vasan, E. J. Geddes, A. Prasanna, P.-C. Wen, W. W. Metcalf, P. J. Hergenrother, E. Tajkhorshid

This study uses molecular dynamics simulations and experimental validation to show that adding a primary amine to antibiotics enhances their permeation through the outer membrane of Gram-negative bacteria by aligning dipole moments and forming electrostatic interactions.

bioRxiv · Aug 10, 2021Biophysics

Saliva-Based Molecular Testing for SARS-CoV-2 that Bypasses RNA Extraction

D. Ranoa, R. Holland, F. G. Alnaji, K. Green, L. Wang, C. Brooke, M. Burke, T. Fan, P. J. Hergenrother

This paper describes a saliva-based SARS-CoV-2 testing method that avoids RNA extraction, achieving a detection limit comparable to nasal swabs and showing good performance with clinical samples.

bioRxiv · Jun 18, 2020 · PreprintMicrobiology

Single-cell analysis of early antiviral gene expression reveals a determinant of stochastic IFNB1 expression

S. Doganay, M. Y. Lee, A. Baum, J. Peh, S.-Y. Hwang, J.-Y. Yoo, P. J. Hergenrother, A. Garcia-Sastre, S. Myong, T. Ha

The paper identifies early antiviral gene expression patterns and shows that RLRs drive stochastic IFNB1 expression independent of IFN.

bioRxiv · Aug 31, 2017Biophysics