Author

E. Kirschke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Myasnikov· 1 shared C. M. Noddings· 1 shared C. Noddings· 1 shared D. A. Agard· 1 shared D. Agard· 1 shared J. L. Johnson· 1 shared R. Y.- R. Wang· 1 shared Z. Roe-Zurz· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 13 mutual co-author links

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1 shared paperBiochemistry

A. Myasnikov

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2 papers

Recent·Most cited

GR chaperone cycle mechanism revealed by cryo-EM: inactivation of GR by GR:Hsp90:Hsp70:Hop client-loading complex

R. Y.- R. Wang, C. M. Noddings, E. Kirschke, A. Myasnikov, J. L. Johnson, D. A. Agard

The paper reports the cryo-EM structure of the GR loading complex, revealing the molecular mechanism of GR inactivation and chaperone coordination.

bioRxiv · Nov 5, 2020 · PreprintBiochemistry

The interplay between Bag-1, Hsp70, and Hsp90 reveals that inhibiting Hsp70 rebinding is essential for Glucocorticoid Receptor activity

E. Kirschke, Z. Roe-Zurz, C. Noddings, D. Agard

This paper investigates the interplay between Bag-1, Hsp70, and Hsp90 in GR reactivation, finding that inhibiting Hsp70 re-binding is critical for GR activity, with Hsp90 playing a unique role in protecting GR from re-inactivation.

bioRxiv · May 3, 2020 · PreprintBiochemistry