A. Myasnikov

Low-dose cryo-electron ptychography of proteins at sub-nanometer resolution

This paper applies low-dose cryo-EM and 4D-STEM ptychography to achieve sub-nanometer resolution 3D reconstructions of frozen hydrated proteins.

Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range

The paper reports cryo-EM structures of mouse ACE2 bound to SARS-CoV-2 VOC Spike proteins, showing mutations enabling immune escape may expand host range.

Structural analysis of the Spike of the Omicron SARS-COV-2 variant by cryo-EM and implications for immune evasion.

The paper reports cryo-EM structures of mouse ACE2 bound to Spike proteins of four SARS-CoV-2 variants, revealing mutations that enhance binding and immune evasion.

GR chaperone cycle mechanism revealed by cryo-EM: inactivation of GR by GR:Hsp90:Hsp70:Hop client-loading complex

The paper reports the cryo-EM structure of the GR loading complex, revealing the molecular mechanism of GR inactivation and chaperone coordination.

Cryo-EM reveals the dynamic interplay between mitochondrial Hsp90 and SdhB folding intermediates

The paper uses cryo-EM to reveal how TRAP1 interacts with SdhB folding intermediates, showing client binding induces structural changes in TRAP1 and provides insights into its role in mitochondrial function.

High-resolution cryo-electron microscopy structure of the Escherichia coli 50S subunit and validation of nucleotide modifications

The paper presents a high-resolution cryo-EM structure of E. coli 50S subunit and develops a program for identifying rRNA modifications using cryo-EM maps.