Identification of Mfn2-S249 as a Phosphoregulatory Switch of Mitochondrial Fusion Dynamics
S. Kumar, A. Ramonett, T. Ahmed, E. Kwak, P. C. Flores, H. R. Ortiz, P. R. Langlais, M. Karthikeyan, N. Y. Lee
The paper identifies Mfn2-S249 as a phosphoregulatory switch controlling mitochondrial fusion dynamics through TAK1-mediated phosphorylation, affecting mitochondrial morphology and energy homeostasis.
bioRxiv · Jan 11, 2022 · PreprintCell Biology