Author

M. Karthikeyan

Tamil Nadu Veterinary and Animal Sciences University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:development & morphogenesis· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

N. Y. Lee· 3 shared A. Ramonett· 2 shared H. R. Ortiz· 2 shared P. C. Flores· 2 shared P. R. Langlais· 2 shared T. Ahmed· 2 shared A Arulmozhi· 1 shared A. ArivuchelvaniD· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersCell Biology

N. Y. Lee

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Author profile →

5 papers

Recent·Most cited

Alternative splice variants of the mitochondrial fission protein DNM1L/Drp1 regulate mitochondrial dynamics and cell fate in ovarian cancer.

Z. Javed, D. H. Shin, W. Pan, S. R. White, Y. S. Kim, A. T. Elhaw, S. Kamlapurkar, Y.-Y. Cheng, J. C. Benson, A. E. Abdelnaby, R. Phaeton, H.-G. Wang, S. Yang, M. L. G. Sullivan, C. St. Croix, , N. Hempel

This study identifies an alternative splice variant of Drp1 in ovarian cancer that promotes metastasis and chemoresistance by altering mitochondrial dynamics.

bioRxiv · Sep 20, 2023Cancer Biology

ER structural remodeling requires TAK1/ATAT1-induced microtubule acetylation

H. R. Ortiz, P. C. Flores, A. Ramonett, T. Ahmed, N. A. Ellis, P. R. Langlais, M. Karthikeyan, N. Y. Lee

The paper shows TAK1 activates TAT1 to acetylate microtubules, promoting ER tubulation and cell survival by downregulating BOK.

bioRxiv · Apr 20, 2023 · PreprintCell Biology

Computational study of Piper betle L. phytocompounds by insilico and ADMET analysis for prediction of potential xanthine oxidase inhibitory activity

P Vikrama Chakravarthi, M. Karthikeyan, L. Lakshmanan, Sankaranarayanan Murugesan, A. Arivuchelvan, K. Sukumar, A Arulmozhi, A. Jagadeeswaran

This study identifies potential xanthine oxidase inhibitors from Piper betle phytocompounds through in silico docking and ADMET analysis, showing some compounds outperform allopurinol.

bioRxiv · Jan 13, 2023 · PreprintBioinformatics

Identification of Mfn2-S249 as a Phosphoregulatory Switch of Mitochondrial Fusion Dynamics

S. Kumar, A. Ramonett, T. Ahmed, E. Kwak, P. C. Flores, H. R. Ortiz, P. R. Langlais, M. Karthikeyan, N. Y. Lee

The paper identifies Mfn2-S249 as a phosphoregulatory switch controlling mitochondrial fusion dynamics through TAK1-mediated phosphorylation, affecting mitochondrial morphology and energy homeostasis.

bioRxiv · Jan 11, 2022 · PreprintCell Biology

BESFA: Bioinformatics based Evolutionary, Structural & Functional Analysis of Prostrate, Placenta, Ovary, Testis, and Embryo (POTE) Paralogs

S. Qazi, B. P. Jit, A. Das, M. Karthikeyan, A. Saxena, M. D. Ray, A. R. Singh, K. Raza, B. Jayaram, A. Sharma

This study analyzes the POTE protein family to understand their structure, function, and adaptive divergence, identifying potential therapeutic applications in cancer.

bioRxiv · Dec 20, 2021Cancer Biology