BiophysicsbioRxiv
Conformational Dynamics In TRPV1 Channels Reported By An Encoded Coumarin Amino Acid
X. Steinberg, M. A. Kasimova, D. Cabezas-Bratesco…·S. E. Brauchi
This study uses a genetically encoded fluorescent amino acid to monitor conformational changes in TRPV1 channels, showing that Y671 fluorescence correlates with channel activation by capsaicin.
DOI 10.7554/elife.28626