Author

M. A. Kasimova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 8

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 4 Approach:mechanistic / dynamical model· 3 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Assay:cryo-EM· 1 Assay:electrophysiology· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

V. Carnevale· 4 shared T. Rohacs· 3 shared A. Deyawe Kongmeneck· 2 shared A. T. Yazici· 2 shared L. Delemotte· 2 shared M. Tarek· 2 shared A. Samanta· 1 shared A. Westerlund· 1 shared

Activity by Year

2017-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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4 shared papersBiophysics

V. Carnevale

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8 papers

Recent·Most cited

Modulation of the IKS channel by PIP2 requires two binding sites per monomer

A. Deyawe Kongmeneck, M. A. Kasimova, M. Tarek

The paper presents molecular models of the KV7.1/KCNE1 complex in different states and shows that two PIP2 lipids are required per monomer to stabilize each state.

bioRxiv · Jan 13, 2021Biophysics

Molecular insights from conformational ensembles via Machine Learning

O. Fleetwood, M. A. Kasimova, A. Westerlund, L. Delemotte

This paper applies machine learning to analyze molecular simulations, identifying interpretable features in biomolecular processes like ligand binding and voltage sensing.

bioRxiv · Dec 8, 2019Biophysics

Two-stage electro-mechanical coupling of a Kv channel in voltage-dependent activation

P. Hou, P. W. Kang, A. Deyawe Kongmeneck, N.-D. Yang, Y. Liu, J. Shi, X. Xu, K. M. White, M. A. Zaydman, M. A. Kasimova, G. Seebohm, L. Zhong, X. Zou, M. Tarek, J. Cui

The paper identifies a two-stage electro-mechanical coupling mechanism in KV7.1 channels, where VSD transitions through intermediate and activated states to trigger pore opening.

bioRxiv · Oct 9, 2019Biophysics

Phosphoinositides regulate the TRPV1 channel via two functionally distinct binding sites

A. T. Yazici, E. Gianti, M. A. Kasimova, V. Carnevale, T. Rohacs

This study resolves a controversy about TRPV1 regulation by showing phosphoinositides act through two distinct binding sites, one inhibitory and one activating.

bioRxiv · Feb 22, 2019 · PreprintBiophysics

Structural insights on TRPV5 gating by endogenous modulators

T. E. T. Hughes, R. A. Pumroy, A. T. Yazici, M. A. Kasimova, E. C. Fluck, K. W. Huynh, A. Samanta, S. Molugu, Z. H. Zhou, V. Carnevale, T. Rohacs, V. Y. Moiseenkova-Bell

The paper determines TRPV5 structures with endogenous modulators PI(4,5)P2 and CaM, revealing their mechanisms of activation and inhibition.

bioRxiv · Jul 31, 2018Biophysics

Molecular basis for voltage sensitivity in membrane proteins

M. A. Kasimova, E. Lindahl, L. Delemotte

The paper introduces a computational method to predict voltage-sensing elements in membrane proteins by analyzing their response to membrane potential changes, identifying residues and ions involved in voltage sensitivity.

bioRxiv · Apr 5, 2018Biophysics

Conformational Dynamics In TRPV1 Channels Reported By An Encoded Coumarin Amino Acid

X. Steinberg, M. A. Kasimova, D. Cabezas-Bratesco, J. Galpin, E. Ladron de Guevara, F. Villa, V. Carnevale, L. D. Islas, C. A. Ahern, S. E. Brauchi

This study uses a genetically encoded fluorescent amino acid to monitor conformational changes in TRPV1 channels, showing that Y671 fluorescence correlates with channel activation by capsaicin.

bioRxiv · May 14, 2017Biophysics

TRPV1 activation relies on hydration/dehydration of nonpolar cavities

M. A. Kasimova, A. Yazici, Y. Yudin, D. Granata, M. L. Klein, T. Rohacs, V. Carnevale

The paper investigates TRPV1 gating mechanisms using simulations and electrophysiology, finding that hydration of nonpolar cavities is critical for channel opening and temperature sensitivity.

bioRxiv · May 5, 2017Biophysics