Conformational Dynamics In TRPV1 Channels Reported By An Encoded Coumarin Amino Acid
X. Steinberg, M. A. Kasimova, D. Cabezas-Bratesco, J. Galpin, E. Ladron de Guevara, F. Villa, V. Carnevale, L. D. Islas, C. A. Ahern, S. E. Brauchi
This study uses a genetically encoded fluorescent amino acid to monitor conformational changes in TRPV1 channels, showing that Y671 fluorescence correlates with channel activation by capsaicin.
bioRxiv · May 14, 2017Biophysics