Author

E. Legrand

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Evolutionary Biology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:plant (other)· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Assay:whole-genome sequencing· 2 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

D. Menard· 3 shared A. Gansane· 2 shared A. M. Kabanywanyi· 2 shared A. Uwimana· 2 shared B. H. Stokes· 2 shared C. H. Cunningham· 2 shared C. Ndayikunda· 2 shared D. A. Fidock· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

D. Menard

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Population genomic evidence of adaptive response during the invasion history of Plasmodium falciparum in the Americas

M. J. M. Lefebvre, J. Daron, E. Legrand, M. C. Fontaine, V. Rougeron, F. Prugnolle

This study analyzes genome-wide polymorphisms in Plasmodium falciparum isolates to investigate its invasion history and adaptive responses in the Americas.

bioRxiv · Oct 30, 2022 · PreprintEvolutionary Biology

Development of a first-in-class unimolecular dual GIP/GLP-2 analogue, GL-0001, for the treatment of bone fragility

B. Gobron, M. Couchot, N. Irwin, E. Legrand, B. Bouvard, G. Mabilleau

This paper introduces GL-0001, a dual GIP/GLP-2 analogue that improves bone ECM material properties and prevents trabecular bone degradation in ovariectomized mice.

bioRxiv · Jul 21, 2022Pharmacology & Toxicology

P. falciparum K13 mutations present varying degrees of artemisinin resistance and reduced fitness in African parasites

B. H. Stokes, K. Rubiano, S. K. Dhingra, S. Mok, J. Straimer, N. F. Gnadig, J. R. Bath, I. Deni, K. E. Ward, J. Striepen, T. Yeo, L. S. Ross, E. Legrand, F. Ariey, C. H. Cunningham, , D. A. Fidock

This study examines K13 mutations in Plasmodium falciparum, showing varying degrees of artemisinin resistance and fitness costs in African parasites, while finding no significant impact on ART susceptibility in Southeast Asian strains.

bioRxiv · Jan 27, 2021 · PreprintPhysiology

Plasmodium falciparum K13 mutations in Africa and Asia present varying degrees of artemisinin resistance and an elevated fitness cost in African parasites

B. H. Stokes, K. Rubiano, S. K. Dhingra, S. Mok, J. Straimer, N. F. Gnadig, J. R. Bath, I. Deni, K. E. Ward, J. Striepen, T. Yeo, L. S. Ross, E. Legrand, F. Ariey, C. H. Cunningham, , D. A. Fidock

bioRxiv · Jan 5, 2021Microbiology

High proportion of multiple copies of Plasmodium falciparum Plasmepsin-2 gene in African isolates: Is piperaquine resistance emerging in Africa?

D. Leroy, F. Macintyre, M. Adamy, B. Laurijssens, R. Klopper, N. Khim, E. Legrand, T. Wells, D. Menard

The paper investigates the prevalence of multiple copies of the Pfpm2 gene in African Plasmodium falciparum isolates and links it to potential piperaquine resistance.

bioRxiv · Jul 3, 2018 · PreprintMicrobiology