Author

B. H. Stokes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:plant (other)· 2 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

D. A. Fidock· 4 shared N. F. Gnadig· 3 shared S. Mok· 3 shared T. Yeo· 3 shared A. Gansane· 2 shared A. M. Kabanywanyi· 2 shared A. Uwimana· 2 shared C. H. Cunningham· 2 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersMicrobiology

D. A. Fidock

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Author profile →

4 papers

Recent·Most cited

Plasmodium falciparum K13 mutations in Africa and Asia present varying degrees of artemisinin resistance and an elevated fitness cost in African parasites

B. H. Stokes, K. Rubiano, S. K. Dhingra, S. Mok, J. Straimer, N. F. Gnadig, J. R. Bath, I. Deni, K. E. Ward, J. Striepen, T. Yeo, L. S. Ross, E. Legrand, F. Ariey, C. H. Cunningham, , D. A. Fidock

eLife · Jul 19, 2021Peer-reviewedMicrobiology

P. falciparum K13 mutations present varying degrees of artemisinin resistance and reduced fitness in African parasites

B. H. Stokes, K. Rubiano, S. K. Dhingra, S. Mok, J. Straimer, N. F. Gnadig, J. R. Bath, I. Deni, K. E. Ward, J. Striepen, T. Yeo, L. S. Ross, E. Legrand, F. Ariey, C. H. Cunningham, , D. A. Fidock

This study examines K13 mutations in Plasmodium falciparum, showing varying degrees of artemisinin resistance and fitness costs in African parasites, while finding no significant impact on ART susceptibility in Southeast Asian strains.

bioRxiv · Jan 27, 2021 · PreprintPhysiology

Plasmodium berghei K13 Mutations Mediate In Vivo Artemisinin Resistance That is Reversed by Proteasome Inhibition

N. V. Simwela, B. H. Stokes, D. Aghabi, M. Bogyo, D. A. Fidock, A. P. Waters

This study introduces K13 mutations into Plasmodium berghei to demonstrate their role in mediating artemisinin resistance in vivo, showing delayed parasite clearance and synergistic effects with proteasome inhibitors.

mBio · Dec 22, 2020Peer-reviewedMicrobiology

The antimalarial natural product salinipostin A identifies essential α/β serine hydrolases involved in lipid metabolism in P. falciparum parasites

E. Yoo, C. J. Schulze, B. H. Stokes, O. Onguka, T. Yeo, S. Mok, N. F. Gnadig, Y. Zhou, K. Kurita, I. T. Foe, S. M. Terrell, M. J. Boucher, P. Cieplak, R. G. Linington, J. Z. Long, , M. Bogyo

The study identifies essential α/β serine hydrolases in P. falciparum as targets of the antimalarial Salinipostin A, which disrupt lipid metabolism and inhibit parasite growth.

bioRxiv · Nov 1, 2019Cell Biology