E. London

Lipid Driven Inter-leaflet Coupling of Plasma Membrane Order Regulates FcεRI Signaling in Mast Cells

This study shows that lipid-driven interleaflet coupling in mast cell membranes regulates FcεRI signaling by modulating inner leaflet order through outer leaflet lipid exchange.

Transbilayer Coupling of Lipids in Cells Investigated by Imaging Fluorescence Correlation Spectroscopy

The paper introduces Imaging Fluorescence Correlation Spectroscopy (ImFCS) to study transbilayer coupling's role in membrane phase separation using model systems.

Cholesterol and sphingomyelin are critical for Fcγ receptor-mediated phagocytosis of Cryptococcus neoformans by macrophages

This study shows that cholesterol and sphingomyelin in lipid rafts are essential for Fcγ receptor-mediated phagocytosis of Cryptococcus neoformans by macrophages.

The Fluorescent Dye 1,6-Diphenyl-1,3,5-Hexatriene Binds to Amyloid Fibrils Formed by Human Amylin and Provides a New Probe of Amylin Amyloid Kinetics

This paper shows that the fluorescent dye DPH binds to human amylin amyloid fibrils, increasing fluorescence, and provides a new tool for studying amylin amyloid kinetics.

LOSS OF PLASMA MEMBRANE LIPID ASYMMETRY CAN INDUCE ORDERED DOMAIN (RAFT) FORMATION

The paper shows that loss of plasma membrane lipid asymmetry can induce ordered domain formation in PMVs, suggesting dynamic asymmetry control regulates raft stability.

Preparation of Asymmetric Vesicles with Trapped CsCl Avoids Osmotic Imbalance, Non-Physiological External Solutions, and Minimizes Leakage

This paper develops a method to prepare asymmetric vesicles using entrapped CsCl to avoid osmotic imbalance and leakage, showing improved stability under physiological conditions.

Phospholipid exchange shows insulin receptor activity is supported by both the propensity to form wide bilayers and ordered domains (rafts)

This study uses lipid exchange to show that insulin receptor activity depends on both bilayer width and ordered domain formation in the plasma membrane.