M. Del Poeta

Step-wise evolution of azole resistance through copy number variation followed by KSR1 loss of heterozygosity in Candida albicans.

This study shows how azole resistance in Candida albicans evolves through copy number variation followed by KSR1 loss of heterozygosity, resulting in a >500-fold resistance increase.

Three models of vaccination strategies against cryptococcosis in immunocompromised hosts using heat-killed Cryptococcus neoformans Δsgl1

This paper evaluates three vaccination strategies using heat-killed Cryptococcus neoformans Δsgl1 to protect against cryptococcosis in immunocompromised hosts, showing robust protection across preventative, therapeutic, and reactivation models.

Microdomain protein Nce102 is a local sensor of plasma membrane sphingolipid balance

The paper shows Nce102 senses sphingolipid balance at the plasma membrane by redistributing in response to sphingolipid demand and regulating sphingolipid synthesis.

Cholesterol and sphingomyelin are critical for Fcγ receptor-mediated phagocytosis of Cryptococcus neoformans by macrophages

This study shows that cholesterol and sphingomyelin in lipid rafts are essential for Fcγ receptor-mediated phagocytosis of Cryptococcus neoformans by macrophages.

Screening of chemical libraries for new antifungal drugs against Aspergillus fumigatus reveals the potential mechanism of action of miltefosine

This study screens 1,127 compounds against Aspergillus fumigatus, identifies miltefosine as fungicidal, and reveals RmiA as a transcription factor regulating sphingolipid biosynthesis involved in miltefosine resistance.

Extracellular vesicles regulate yeast growth, biofilm formation, and yeast-to-hypha differentiation in Candida albicans

This study shows that extracellular vesicles from Candida albicans inhibit biofilm formation, yeast-to-hypha differentiation, and virulence by altering gene expression and morphology.

Internalization of the host alkaline pH signal in a fungal pathogen

This study identifies how the Rra1 protein in Cryptococcus neoformans internalizes and recycles in response to alkaline pH, enabling the fungus to adapt to the human host environment.

Fenbendazole controls in vitro growth, virulence potential and animal infection in the Cryptococcusmodel

This study shows fenbendazole inhibits Cryptococcus growth in vitro and in mice, reduces virulence, and synergizes with amphotericin B.