S. A. Gerber

P. aeruginosa tRNA-fMet halves secreted in outer membrane vesicles suppress lung inflammation in Cystic Fibrosis

This paper shows tobramycin reduces inflammation in cystic fibrosis by increasing 5' tRNA-fMet halves in P. aeruginosa outer membrane vesicles, which suppress IL-8 and neutrophilic inflammation in human cells and mice.

Acetylation of WCC is dispensable for the core circadianclock but differentially regulates acute light responses in Neurospora

This study shows acetylation and mono-methylation of WCC in Neurospora are not essential for circadian rhythm timing but influence light responses.

Local Delivery of SBRT and IL12 by mRNA Technology Overcomes Immunosuppressive Barriers to Eliminate Pancreatic Cancer

This paper demonstrates a combination treatment of SBRT and IL-12 mRNA in murine pancreatic tumors, achieving cures in both primary and metastatic models by enhancing T cell responses.

Pharmacological Induction of mesenchymal-epithelial transition chemosensitizes breast cancer cells and prevents metastatic progression

The paper shows that eribulin induces MET in mesenchymal-like TNBC cells, reducing metastatic potential and increasing sensitivity to other chemotherapeutics.

Quantitative phosphoproteomics reveals regulatory state dependent efficacy of chemical Cdk1 inhibition and distinct Cdk5 complexes as novel Wee1 substrates

This study uses phosphoproteomics to show Wee1-dependent phosphorylation of Cdk1-cyclin B enhances RO3306 inhibition and identifies Cdk5 complexes as new Wee1 substrates.

Chromosome segregation fidelity is controlled by small changes in kinetochore phospho-occupancy

The paper measures phospho-occupancy on Hec1 to show small changes in phosphorylation control chromosome segregation fidelity through kinase and phosphatase networks.

Targeting Vitamin-D receptor (VDR) by a small molecule antagonist MeTC7 inhibits PD-L1 but controls THMYCN neuroblastoma growth PD-L1 independently

This study shows that MeTC7, a VDR antagonist, reduces PD-L1 expression in cancer cells and inhibits neuroblastoma growth independently of PD-L1.

Dual Energy X-ray Absorptiometry (DEXA) as a Longitudinal Outcome Measure of Cancer-Related Muscle Wasting in Mice

This study validates DEXA as a longitudinal measure of lean body mass and skeletal muscle wasting in a PDAC mouse model.

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

This study shows CDK12 inhibition causes premature cleavage and polyadenylation in long DNA damage response genes, linked to their length and polyadenylation site distribution.