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A host ATPase essential for rhinovirus replication is an antiviral target with a high barrier to resistance

This study identifies RUVBL1/2 as a host ATPase essential for rhinovirus replication and shows that its inhibition effectively blocks viral replication without resistance development.

Age-dependent expression and antiviral activity of interferon epsilon in respiratory epithelium

This study shows that IFNE expression decreases in infants, leading to reduced antiviral activity against RSV, suggesting a role in early-life RSV susceptibility.

Myoferlin is an essential component of late-stage vRNP trafficking vesicles for enveloped RNA viruses.

The paper identifies myoferlin as a conserved host factor essential for late-stage vRNP trafficking in enveloped RNA viruses like IAV, RSV, and SeV.

The cold-inducible RNA-binding protein RBM3 stabilises viral mRNA at the cooler temperatures of the upper respiratory tract.

This study identifies RBM3 as a host factor that stabilizes influenza A virus mRNA at cooler temperatures, enhancing viral replication in the upper respiratory tract.