PhysiologybioRxivPreprint
Antibody-mediated depletion of human CLEC-2 in a novel humanised mouse model
H. C. Brown, S. Beck, S. Navarro…·D. Stegner
This paper develops a humanised CLEC-2 mouse model and a monoclonal antibody to test anti-CLEC-2 therapeutics, showing transient thrombocytopenia without affecting haemostasis.
DOI 10.1101/2021.10.03.462933