B. Nieswandt

Loss of zinc transporters ZIP1 and ZIP3 augments platelet reactivity in response to G protein-coupled receptor agonists and accelerates thrombus formation in vivo

This study shows that loss of ZIP1 and ZIP3 in mice leads to increased platelet reactivity and faster thrombus formation, despite normal Zn2+ levels.

G6b-B regulates an essential step in megakaryocyte maturation

This study identifies G6b-B's critical role in early megakaryocyte differentiation by analyzing a mouse model with a mutation causing macrothrombocytopenia and myelofibrosis.

Microthrombocytopenia caused by impaired microtubule stability in RhoB-deficient mice

This study shows that RhoB deficiency in mice causes microthrombocytopenia due to impaired microtubule stability, distinct from RhoA's role.

Antibody-mediated depletion of human CLEC-2 in a novel humanised mouse model

This paper develops a humanised CLEC-2 mouse model and a monoclonal antibody to test anti-CLEC-2 therapeutics, showing transient thrombocytopenia without affecting haemostasis.

Loss of Hem1 disrupts macrophage function and impacts on migration, phagocytosis and integrin-mediated adhesion

This study shows that Hem1 deficiency impairs macrophage migration, phagocytosis, and integrin-mediated adhesion by disrupting WRC function and paxillin phosphorylation.

Mapping densely packed GPIIb/IIIa receptors in murine blood platelets with expansion microscopy

This paper uses expansion microscopy to study GPIIb/IIIa receptor distribution in murine platelets, revealing clusters in resting platelets that persist through activation.

C-type lectin-like receptor 2 (CLEC-2)-dependent DC migration is controlled by tetraspanin CD37

This study shows that CD37 stabilizes CLEC-2 membrane expression and regulates DC migration to lymph nodes via interactions with podoplanin.