Author

S. G. Thomas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Immunology· 1 Physiology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 4 Organism:human· 4 Organism:mouse· 4 Assay:proteomics· 3 Approach:microscopy & imaging analysis· 2 Organism:Arabidopsis· 1

Frequent Co-Authors

S. P. Watson· 3 shared A. O. Khan· 2 shared A. Slater· 2 shared E. Garlick· 2 shared J. A. Pike· 2 shared J. Yule· 2 shared M. zuidscherwoude· 2 shared N. V. Morgan· 2 shared

Activity by Year

2018-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersPhysiology

S. P. Watson

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Antibody-mediated depletion of human CLEC-2 in a novel humanised mouse model

H. C. Brown, S. Beck, S. Navarro, Y. Di, E. M. Soriano Jerez, J. Kaczmarzyk, S. G. Thomas, V. Mirakaj, S. P. Watson, B. Nieswandt, D. Stegner

This paper develops a humanised CLEC-2 mouse model and a monoclonal antibody to test anti-CLEC-2 therapeutics, showing transient thrombocytopenia without affecting haemostasis.

bioRxiv · Oct 3, 2021 · PreprintPhysiology

Analysis of Preplatelets and Their Barbell Platelet Derivatives by Imaging Flow Cytometry

S. Kemble, A. L. Dalby, G. C. Lowe, P. L. Nicolson, S. P. Watson, Y. A. Senis, S. G. Thomas, P. Harrison

This study uses imaging flow cytometry and microscopy to show that preplatelets and barbell platelets are immature structures that transform into mature platelets in mice and humans.

bioRxiv · Jul 30, 2021Cell Biology

Nitrate-regulated growth processes involve activation of gibberellin pathway

L. Camut, B. Gallova, L. Jilli, M. Sirlin-Josserand, E. Carrera, L. Sakvarelidze-Achard, J. Zumsteg, D. Heintz, S. Ruffel, G. Krouk, S. G. Thomas, P. Hedden, A. L. Phillips, J.-M. Daviere, P. Achard

This study shows nitrate promotes plant growth in Arabidopsis and wheat by modulating gibberellin-regulated DELLA repressors through GA metabolism.

bioRxiv · Jul 27, 2021 · PreprintPlant Biology

Simple methods for quantifying super-resolved cortical actin

E. Garlick, E. L. Faulkner, S. J. Briddon, S. G. Thomas

This paper develops and validates methods to quantify super-resolved cortical actin structures using SRRF and ExM, showing increased corral area with cytochalasin D treatment.

bioRxiv · May 26, 2021Cell Biology

CLEC-2 promotes inflammatory peritoneal macrophage emigration to draining lymph nodes during endotoxemia

J. H. Bourne, N. Beristain Covarrubias, M. zuidscherwoude, J. Campos, Y. Di, E. Garlick, M. Colicchia, L. V. Terry, S. G. Thomas, A. Brill, J. Barry, S. P. Watson, J. Rayes

This study identifies that recombinant CLEC-2-Fc promotes the emigration of inflammatory peritoneal macrophages to draining lymph nodes, reducing local inflammation during endotoxemia.

bioRxiv · Dec 21, 2020 · PreprintImmunology

Post-translational polymodification of β1 tubulin regulates motor protein localisation in platelet production and function

A. O. Khan, A. Slater, A. Maclachlan, P. L. Nicolson, J. A. Pike, J. S. S. Reyat, J. Yule, R. Stapley, S. G. Thomas, N. V. Morgan

The paper investigates how post-translational polymodifications of β1 tubulin regulate motor protein localization in platelet production and function using patient data, iPSC-derived megakaryocytes, and platelets.

Haematologica · Dec 17, 2020Peer-reviewedCell Biology

The FH2 domain of formin proteins is critical for platelet cytoskeletal dynamics

H. L. H. Green, M. Zuidscherwoude, S. G. Thomas

This study shows that inhibiting the FH2 domain of formin proteins blocks platelet spreading and disrupts actin and microtubule organization without affecting aggregation or secretion.

bioRxiv · Mar 26, 2019Cell Biology

Optimised CRISPR-Cas9 mediated single molecule imaging for accurate quantification through endogenous expression.

A. O. Khan, C. W. White, J. A. Pike, J. Yule, A. Slater, S. J. Hill, N. S. Poulter, S. G. Thomas, N. V. Morgan

This study optimizes CRISPR-Cas9 for single molecule imaging by improving mEos variants and shows endogenous labeling enables accurate quantification of CXCR4.

bioRxiv · Nov 30, 2018 · PreprintCell Biology