PI3K-dependant reprogramming of hexokinase isoforms controls glucose metabolism and functional responses of B lymphocytes
B. Paradoski, S. Hou, E. Mejia, F. Adefemi-Olayinka, D. Fowke, G. M. Hatch, A. Saleem, V. Banerji, N. Hay, H. Zeng, A. Marshall
This study shows that PI3K-dependent upregulation of hexokinase 2 (HK2) controls glucose metabolism and immune functions in B cells, with HK2-deficient B cells showing impaired metabolic and functional responses.
bioRxiv · Feb 29, 2024Immunology