G. M. Hatch

PI3K-dependant reprogramming of hexokinase isoforms controls glucose metabolism and functional responses of B lymphocytes

This study shows that PI3K-dependent upregulation of hexokinase 2 (HK2) controls glucose metabolism and immune functions in B cells, with HK2-deficient B cells showing impaired metabolic and functional responses.

Reduction in mRNA expression of the neutrophil chemoattract factor CXCL1 in Pseudomonas aeruginosa treated Barth Syndrome B lymphoblasts

The paper examines CXCL1 mRNA expression in BTHS B lymphoblasts before and after Pseudomonas aeruginosa treatment, finding significant reductions in both conditions.

Reduction in cardiolipin reduces expression of creatine transporter-1 and creatine transport in hBMEC/D3 human brain microvessel endothelial cells

This study shows that reducing cardiolipin in hBMEC/D3 cells decreases creatine transporter-1 expression and creatine transport, while not affecting fatty acid transport.

Tafazzin knockdown in murine mesenchymal stem cells enhances the tafazzin knockdown mediated elevation in interleukin-10 secretion from murine B lymphocytes

The paper shows that Taz deficiency in murine MSCs enhances IL-10 secretion from Taz-deficient B cells when co-cultured.

Tissue Specific Knockout of the Cardiolipin Transacylase Enzyme TAFAZZIN in Both Liver and Pancreatic Beta Cells Protects Mice From Diet-Induced Obesity

This study shows that knocking out tafazzin in both liver and pancreatic beta cells protects mice from diet-induced obesity by reducing weight gain and fat accumulation.

Altered Cardiolipin Metabolism is Associated with Cardiac Mitochondrial Dysfunction in Pulmonary Vascular Remodeled Perinatal Rat Pups

This study examines phospholipid metabolism in perinatal rat pups with pulmonary vascular remodeling, finding altered cardiolipin and phosphatidylethanolamine levels linked to mitochondrial dysfunction and cardiac dysfunction.

Tafazzin deficiency in mouse mesenchymal stem cells potentiates their immunosuppression and impairs activated B lymphocyte immune function

This study shows that Tafazzin deficiency in mouse mesenchymal stem cells enhances their immunosuppressive effects on activated B lymphocytes.

Reduced protein kinase C delta association with a higher molecular weight complex in mitochondria of Barth Syndrome lymphoblasts

The paper examines reduced PKCδ association with a higher molecular weight complex in mitochondria of Barth Syndrome lymphoblasts, linking it to impaired mitochondrial function.

Tafazzin regulates the function of lipopolysaccharide activated B lymphocytes in mice

This study shows that tafazzin deficiency impairs B cell function and metabolism in response to lipopolysaccharide in mice.

Misoprostol Treatment Prevents Hypoxia-Induced Cardiac Dysfunction Through a 14-3-3 and PKA regulatory motif on Bnip3

This study shows misoprostol prevents hypoxia-induced cardiac dysfunction by phosphorylating Bnip3, altering its localization and reducing necroinflammation and mitochondrial damage.

Misoprostol Attenuates Cardiomyocyte Proliferation in the Neonatal Heart Through Bnip3 and Perinuclear Calcium Signaling

This study shows misoprostol reduces neonatal cardiomyocyte proliferation via Bnip3 and calcium signaling, offering potential therapeutic benefits for neonatal heart conditions.

Berberine alleviates adiposity and cardiac dysfunction in offspring exposed to gestational diabetes mellitus

This study shows that berberine treatment reduces adiposity and improves cardiac and pancreatic function in offspring exposed to gestational diabetes mellitus.

Misoprostol regulates Bnip3 repression and alternative splicing to control cellular calcium homeostasis during hypoxic stress.

This study shows misoprostol reduces Bnip3 expression and promotes alternative splicing to protect cells from hypoxia-induced damage by regulating calcium homeostasis.