A. Saleem

Omega-3 polyunsaturated fatty acids modify glucose metabolism in THP-1 monocytes

This study shows that ALA and DHA reduce oxidative phosphorylation and increase glycolysis in THP-1 monocytes, possibly via upregulation of PDK4.

PI3K-dependant reprogramming of hexokinase isoforms controls glucose metabolism and functional responses of B lymphocytes

This study shows that PI3K-dependent upregulation of hexokinase 2 (HK2) controls glucose metabolism and immune functions in B cells, with HK2-deficient B cells showing impaired metabolic and functional responses.

The mitophagy receptor BNIP3L/Nix coordinates nuclear calcium signaling to modulate the muscle phenotype.

This study shows Nix regulates muscle phenotype by coordinating mitophagy, ER-phagy, and nuclear calcium signaling, affecting insulin sensitivity and fiber-type composition.

Unique Pakistani gut microbiota highlights population-specific microbiota signatures of type 2 diabetes mellitus

The paper analyzes the gut microbiota of Pakistani adults with and without T2D, finding unique microbial signatures and associations with inflammation markers.

In-silico comparative modeling and interaction studies of PRSV proteins - Accelerated towards dissection of structure based evolutionary divergence and functional interaction of virus within the host

The paper uses in-silico modeling to analyze the structure and interactions of PRSV-PK proteins, revealing evolutionary divergence and potential host-virus interactions.

Skeletal muscle-derived extracellular vesicles are altered with chronic contractile activity: a dynamic light scattering analysis

This study shows chronic contractile activity reduces the size and zeta potential of skeletal muscle-derived extracellular vesicles using dynamic light scattering.

Profiling skeletal muscle-derived secretome with differentiation and acute contractile activity

This study compares extracellular vesicles from skeletal muscle cells before and after differentiation, finding differences in size, protein yield, and marker expression, but no effect of acute contractile activity.

Novel Association of Lyme Disease, Age, and Atopic Dermatitis

This study identifies a novel association between Lyme disease, age, and atopic dermatitis using both murine models and human epidemiological data.

Extracellular vesicles as predictors of individual response to exercise training in youth living with obesity

This study examines if changes in extracellular vesicles after acute exercise predict response to resistance training in youth with obesity, finding differences in EV size and protein content between responders and non-responders.

Hierarchical design of multi-scale protein complexes by combinatorial assembly of oligomeric helical bundle and repeat protein building blocks

This paper describes a hierarchical method to design multi-scale symmetric protein complexes using repeat proteins and helical bundles, resulting in large symmetric assemblies like an icosahedral nanocage.