DARPP-32 and t-DARPP promote lung cancer growth through IKKα-dependent cell migration and Akt/Erk-mediated cell survival
S. K. Alam, M. Astone, P. Liu, S. R. Hall, A. M. Coyle, E. N. Dankert, D. K. Hoffman, W. Zhang, R. Kuang, A. C. Roden, A. S. Mansfield, L. H. Hoeppner
The paper shows that DARPP-32 and t-DARPP promote lung cancer growth via IKKα-dependent migration and Akt/Erk-mediated survival, with t-DARPP linked to poor survival and higher tumor stages.
bioRxiv · Dec 6, 2017Cancer Biology