S. R. Hall

Dermonecrosis caused by spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib

This study identifies toxin synergism in spitting cobra venom causing dermonecrosis and shows that varespladib prevents tissue damage in mouse models.

Machine-learning guided Venom Induced Dermonecrosis Analysis tooL: VIDAL

VIDAL is a machine-learning tool that automatically analyzes dermonecrosis in mouse models to assess antivenom efficacy, offering an accurate and reproducible alternative to manual methods.

Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms

The paper shows repurposed drugs and their combinations reduce cytotoxicity of snake venoms in cell and mouse models, offering potential new treatments for snakebite envenoming.

Two snakebite antivenoms have potential to reduce Eswatini's dependency upon a single, increasingly unavailable product: results of preclinical efficacy testing

This study evaluates two antivenoms as alternatives to SAIMR Polyvalent in Eswatini, finding they are equally or more effective against the most common snake venom but less effective against others.

Exploring the utility of recombinantly expressed snake venom serine protease toxins as immunogens for generating experimental snakebite antivenoms

This study evaluates recombinant snake venom serine protease toxins as immunogens to generate antivenoms that target specific venom-induced pathologies.

In vitro and in vivo venom-inhibition assays identify metalloproteinase-inhibiting drugs as potential treatments for snakebite envenoming by Dispholidus typus

This study evaluates four SVMP inhibitors for treating D. typus snakebite envenoming, finding DMPS and marimastat effective in preclinical models.

A paradox of parasite resistance: Disease-driven trophic cascades increase the cost of resistance, selecting for lower resistance with parasites than without them

The paper shows that parasites can reduce host resistance through resource feedbacks, contradicting the expectation that parasites increase resistance during epidemics.

Niche theory for within-host parasite dynamics: Analogies to food web modules via feedback loops

The paper uses food web models to explain the dynamic behavior of parasites within hosts, showing how feedback loops influence coexistence and competition outcomes.

Parasite-driven cascades or hydra effects: susceptibility and foraging depression shape parasite-host-resource interactions

The paper investigates how parasite-driven mortality and foraging depression influence host density during epidemics, revealing conditions under which trophic cascades or hydra effects occur.

'Resistance is futile': Weaker selection for resistance during larger epidemics further increases prevalence and depresses host density

The paper shows that higher epidemic drivers lead to lower host resistance, increasing parasite prevalence and reducing host density through mathematical, experimental, and field analyses.

Virulent disease epidemics can increase host density by depressing foraging of hosts

The paper shows that virulent parasites can increase host density by reducing infected hosts' foraging rates, leading to a hydra effect in ecosystems.

DARPP-32 and t-DARPP promote lung cancer growth through IKKα-dependent cell migration and Akt/Erk-mediated cell survival

The paper shows that DARPP-32 and t-DARPP promote lung cancer growth via IKKα-dependent migration and Akt/Erk-mediated survival, with t-DARPP linked to poor survival and higher tumor stages.