Author

A. C. Roden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

L. H. Hoeppner· 2 shared S. K. Alam· 2 shared A. Bychkov· 1 shared A. Cavazza· 1 shared A. M. Coyle· 1 shared A. M. Marchevsky· 1 shared A. M. Takano· 1 shared A. S. Mansfield· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

L. H. Hoeppner

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Author profile →

3 papers

Recent·Most cited

Deep learning for histopathological subtyping and grading of lung adenocarcinoma

K. Lami, N. Ota, S. Yamaoka, A. Bychkov, K. Matsumoto, W. Uegami, R. Attanoos, S. Berezowska, L. Brcic, A. Cavazza, J. English, A. T. Fabro, K. Ishida, Y. Kashima, Y. Kitamura, , J. Fukuoka

This study develops CNNs to subtype and grade lung adenocarcinoma, achieving high accuracy and outperforming most pathologists in grading prediction.

bioRxiv · Nov 2, 2022 · PreprintPathology

ASCL1-regulated DARPP-32 and t-DARPP stimulate small cell lung cancer growth and neuroendocrine tumor cell survival

S. K. Alam, L. Wang, Y. Ren, C. E. Hernandez, F. Kosari, A. C. Roden, R. Yang, L. H. Hoeppner

The paper shows that ASCL1-regulated DARPP-32 and t-DARPP promote SCLC growth and survival through Akt/Erk signaling and anti-apoptotic pathways, with t-DARPP overexpression linked to Notch signaling activation in SCLC patients.

bioRxiv · Jul 16, 2019Cancer Biology

DARPP-32 and t-DARPP promote lung cancer growth through IKKα-dependent cell migration and Akt/Erk-mediated cell survival

S. K. Alam, M. Astone, P. Liu, S. R. Hall, A. M. Coyle, E. N. Dankert, D. K. Hoffman, W. Zhang, R. Kuang, A. C. Roden, A. S. Mansfield, L. H. Hoeppner

The paper shows that DARPP-32 and t-DARPP promote lung cancer growth via IKKα-dependent migration and Akt/Erk-mediated survival, with t-DARPP linked to poor survival and higher tumor stages.

bioRxiv · Dec 6, 2017Cancer Biology