A 3UTR-derived small RNA modulates the life-cycle of the cholera toxin-encoding filamentous phage, CTXphi
Anne Lippegaus, James R. J. Haycocks, E. O'Driscoll, Marcel Sprenger, Kerstin Thriene, Elke‐Martina Jung, Malte Siemers, Sebastian Krautwurst, David C. Grainger, Kai Papenfort
The paper identifies and characterizes CisR, a small RNA that inhibits CTXφ phage production by repressing cep mRNA through Hfq-dependent base-pairing, linking phage activation to cell density and nutrient availability in V. cholerae.
Proceedings of the National Academy of Sciences · Jun 2, 2026Peer-reviewedMicrobiology