The N-glycosylation defect in Lec5 and Lec9 CHO cells is caused by absence of the DHRSX gene
Takfarinas Kentache, Charlotte R. Althoff, Francesco Caligiore, Erika L. Souche, Céline Schulz, Julie Graff, E. Pieters, Pamela Stanley, Joseph N. Contessa, Emile VAN SCHAFTINGEN, Gert Matthijs, François Foulquier, Guido T. Bommer, Matthew P. Wilson
This study identifies DHRSX gene absence as the cause of dolichol synthesis defect in Lec5 and Lec9 CHO cells, correcting N-glycosylation defects through DHRSX complementation.
Journal of Biological Chemistry · Oct 10, 2024Peer-reviewedBiochemistry