Joseph N. Contessa

This study identifies JAK1 as a driver of tumor cell radiosensitivity and shows that Kif18a inhibition can counteract therapeutic resistance by exacerbating mitotic stress.

This study shows that PLK4 inhibition with CFI-400945 enhances radiosensitivity of NSCLC cells but not normal fibroblasts by increasing mitotic catastrophe and centrosome amplification.

The paper develops OST inhibitors that selectively target STT3A and STT3B, leading to tumor regression in EGFR-mutant lung cancer models.

This study identifies DHRSX gene absence as the cause of dolichol synthesis defect in Lec5 and Lec9 CHO cells, correcting N-glycosylation defects through DHRSX complementation.