E. S. Sattely

Gut microbiota gate host exposure to cholinesterase inhibitors from dietary Solanums

The paper investigates how gut microbiota modify steroidal alkaloids from Solanum plants, affecting host exposure and physiological effects.

Reconstitution of Early Paclitaxel Biosynthetic Network

This paper reconstitutes an early paclitaxel biosynthetic network by engineering Taxus genes to increase taxadien-5-ol accumulation and identify pathway byproducts.

Neofunctionalized carbonic anhydrases in the biosynthesis of neuroactive plant alkaloids

The paper identifies neofunctionalized carbonic anhydrases involved in the biosynthesis of neuroactive Lycopodium alkaloids and describes their role in scaffold tailoring for acetylcholinesterase inhibition.

Complex scaffold remodeling in plant triterpene biosynthesis

The paper identifies 22 enzymes involved in limonoid biosynthesis, enabling the total synthesis of kihadalactone A and azadirone in a heterologous plant.

Modular and programmable RNA sensing using ADAR editing in living cells

This paper introduces RADAR, a modular and programmable RNA sensing system that can detect specific RNA sequences and mutations in human and mouse cells.

A plant host enables the heterologous production and combinatorial study of fungal lignin-degrading enzymes

The paper demonstrates that Nicotiana benthamiana can produce fungal lignin-degrading enzymes and shows that peroxidase specialization affects C-C bond cleavage during lignin oxidation.

A metabolic pathway for glucosinolate activation by the human gut symbiont Bacteroides thetaiotaomicron

This study identifies a metabolic pathway in Bacteroides thetaiotaomicron for glucosinolate activation into isothiocyanates, showing its role in processing dietary nutrients.

Plant-derived coumarins shape the composition of an Arabidopsis synthetic root microbiome

The paper investigates how coumarins from Arabidopsis roots influence the microbiome under iron deficiency, showing they inhibit a Pseudomonas strain via redox mechanisms.

Secretion of redox-active metabolites as a general strategy for iron acquisition in plants

This study identifies sideretin, a redox-active metabolite secreted by Arabidopsis roots under iron deficiency, and shows its role in iron acquisition through reduction, suggesting a widespread strategy in eudicots.