Author

C. R. Fischer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 2 Biochemistry· 1 Cancer Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:metabolomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

J. L. Sonnenburg· 2 shared S. K. Higginbottom· 2 shared A. E. McShane· 1 shared A. Li· 1 shared A. P. Klein· 1 shared B. A. H. Smith· 1 shared B. C. DeFelice· 1 shared B. D. Merrill· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

J. L. Sonnenburg

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A metabolomics pipeline enables mechanistic interrogation of the gut microbiome

S. Han, W. Van Treuren, C. R. Fischer, B. D. Merrill, B. C. DeFelice, J. M. Sanchez, S. K. Higginbottom, L. Guthrie, L. A. Fall, D. Dodd, M. A. Fischbach, J. L. Sonnenburg

The paper develops a metabolomics pipeline to identify microbiota-dependent metabolites and explores their links to host phenotypes using machine learning and comparative genomics.

bioRxiv · May 25, 2021Microbiology

Complete Reconstitution and Deorphanization of the 3 MDa NOCAP (NOCardiosis-Associated Polyketide) Synthase

K. P. Yuet, C. W. Liu, S. R. Lynch, J. Kuo, W. Michaels, R. B. Lee, A. E. McShane, B. L. Zhong, C. R. Fischer, C. Khosla

The paper reconstitutes and deorphanizes a nonamodular PKS from Nocardia strains, identifying the NOCAP aglycone structure through in vitro and heterologous expression methods.

bioRxiv · Jan 28, 2020Biochemistry

A metabolic pathway for glucosinolate activation by the human gut symbiont Bacteroides thetaiotaomicron

C. S. Liou, S. J. Sirk, C. A. Diaz, A. P. Klein, C. R. Fischer, S. K. Higginbottom, J. L. Sonnenburg, E. S. Sattely

This study identifies a metabolic pathway in Bacteroides thetaiotaomicron for glucosinolate activation into isothiocyanates, showing its role in processing dietary nutrients.

bioRxiv · May 2, 2019 · PreprintMicrobiology

Systematic identification of regulators of antibody-drug conjugate toxicity using CRISPR-Cas9 screens

C. K. Tsui, R. M. Barfield, C. R. Fischer, D. W. Morgens, A. Li, B. A. H. Smith, C. R. Bertozzi, D. Rabuka, M. C. Bassik

This study uses CRISPR-Cas9 screens to identify genes regulating antibody-drug conjugate (ADC) toxicity, revealing endolysosomal trafficking regulators and mechanisms of ADC resistance.

bioRxiv · Mar 3, 2019 · PreprintCancer Biology

A pathogen-responsive gene cluster for the production of highly modified fatty acids in tomato

J. E. Jeon, J.-G. Kim, C. R. Fischer, C. Dufour-Schroif, K. Wemmer, M. B. Mudgett, E. Sattely

The paper identifies a gene cluster in tomato required for producing falcarindiol, an antifungal lipid, in response to fungal pathogens.

bioRxiv · Sep 4, 2018Plant Biology