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2 papers
Recent·Most cited
M. Lim, T. Do Cong, L. M. Orr, E. S. Toriki, A. C. Kile, J. W. Papatzimas, E. Lee, D. K. Nomura
This study identifies a covalent handle that enables the degradation of multiple protein targets when appended to protein-targeting ligands.
bioRxiv · Feb 20, 2024Biochemistry
E. S. Toriki, J. W. Papatzimas, K. Nishikawa, D. Dovala, L. M. McGregor, M. J. Hesse, J. M. McKenna, J. A. Tallarico, M. Schirle, D. K. Nomura
This paper develops a strategy to convert protein-targeting ligands into molecular glue degraders by identifying a covalent handle that induces proteasome-mediated degradation of target proteins.
bioRxiv · Nov 4, 2022Biochemistry