Author

L. M. McGregor

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 4 Organism:human· 3 Assay:proteomics· 2

Frequent Co-Authors

D. K. Nomura· 4 shared J. A. Tallarico· 4 shared J. M. McKenna· 4 shared M. Schirle· 4 shared D. Dovala· 2 shared J. N. Spradlin· 2 shared S. M. Brittain· 2 shared T. J. Maimone· 2 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersBiochemistry

D. K. Nomura

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4 papers

Recent·Most cited

Rational Chemical Design of Molecular Glue Degraders

E. S. Toriki, J. W. Papatzimas, K. Nishikawa, D. Dovala, L. M. McGregor, M. J. Hesse, J. M. McKenna, J. A. Tallarico, M. Schirle, D. K. Nomura

This paper develops a strategy to convert protein-targeting ligands into molecular glue degraders by identifying a covalent handle that induces proteasome-mediated degradation of target proteins.

bioRxiv · Nov 4, 2022Biochemistry

Deubiquitinase-Targeting Chimeras for Targeted Protein Stabilization

N. J. Henning, L. Boike, J. N. Spradlin, C. C. Ward, B. Belcher, S. M. Brittain, M. Hesse, D. Dovala, L. M. McGregor, J. M. McKenna, J. A. Tallarico, M. Schirle, D. K. Nomura

This paper introduces the DUBTAC platform for targeted protein stabilization by linking a covalent OTUB1 recruiter to lumacaftor, demonstrating stabilization of ΔF508-CFTR in human cells.

bioRxiv · Apr 30, 2021Biochemistry

A Nimbolide-Based Kinase Degrader Preferentially Degrades Oncogenic BCR-ABL

B. Tong, J. N. Spradlin, L. F. T. Novaes, E. Zhang, X. Hu, M. Moeller, S. M. Brittain, L. M. McGregor, J. M. McKenna, J. A. Tallarico, M. Schirle, T. J. Maimone, D. K. Nomura

This paper develops a PROTAC molecule, BT1, that selectively degrades BCR-ABL over c-ABL in leukemia cells using nimbolide as an E3 ligase recruiter, showing additional anti-proliferative effects.

bioRxiv · Apr 2, 2020Biochemistry

Manumycin Polyketides Act as Molecular Glues Between UBR7 and P53 to Impair Breast Cancer Pathogenicity

Y. Isobe, M. Okumura, R. White, L. M. McGregor, J. M. McKenna, J. A. Tallarico, M. Schirle, T. J. Maimone, D. K. Nomura

The paper identifies manumycin polyketides as molecular glues that bind UBR7 and P53, impairing breast cancer pathogenicity through p53 activation and cell death.

bioRxiv · Oct 22, 2019 · PreprintBiochemistry