Author

M. J. Hesse

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 2 Approach:comparative / phylogenetic analysis· 1

Frequent Co-Authors

D. Dovala· 3 shared D. K. Nomura· 3 shared J. M. McKenna· 3 shared M. Schirle· 3 shared J. A. Tallarico· 2 shared C. C. Ward· 1 shared C. M. Zammit· 1 shared D. Fuller· 1 shared

Activity by Year

2022-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBiochemistry

D. Dovala

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Targeted Protein Degradation through E2 Recruitment

N. Forte, D. Dovala, M. J. Hesse, J. M. McKenna, J. A. Tallarico, M. Schirle, D. K. Nomura

This study identifies a covalent recruiter for the E2 ubiquitin conjugating enzyme UBE2D, enabling targeted protein degradation via PROTACs.

bioRxiv · Dec 19, 2022 · PreprintBiochemistry

Rational Chemical Design of Molecular Glue Degraders

E. S. Toriki, J. W. Papatzimas, K. Nishikawa, D. Dovala, L. M. McGregor, M. J. Hesse, J. M. McKenna, J. A. Tallarico, M. Schirle, D. K. Nomura

This paper develops a strategy to convert protein-targeting ligands into molecular glue degraders by identifying a covalent handle that induces proteasome-mediated degradation of target proteins.

bioRxiv · Nov 4, 2022Biochemistry

Discovery of Potent Pyrazoline-Based Covalent SARS-CoV-2 Main Protease Inhibitors

P. Moon, L. Boike, D. Dovala, N. J. Henning, M. Knapp, J. N. Spradlin, C. C. Ward, H. Wolleb, C. M. Zammit, D. Fuller, G. Blake, J. P. Murphy, F. Wang, Y. Lu, S. A. Moquin, , D. K. Nomura

This study identifies and optimizes potent pyrazoline-based covalent inhibitors of SARS-CoV-2 Mpro, showing activity against multiple coronaviruses.

bioRxiv · Mar 5, 2022Biochemistry