Author

E. Saccon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 3 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 5 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Vegvari· 4 shared F. Mikaeloff· 4 shared S. Gupta· 4 shared U. Neogi· 4 shared A. Sonnerborg· 3 shared J. E. Rodriguez· 3 shared A. Mirazimi· 2 shared B. S. Vinhas· 2 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersMicrobiology

A. Vegvari

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Implications of central carbon metabolism in SARS-CoV-2 replication and disease severity

S. Krishnan, H. Nordqvist, A. T. Ambikan, S. Gupta, M. Sperk, S. Svensson-Akusjarvi, F. Mikaeloff, R. Benfeitas, E. Saccon, S. M. Ponnan, J. E. Rodriguez, N. Nikouyan, A. Odeh, G. Ahlen, M. Asghar, , U. Neogi

This study investigates how SARS-CoV-2 affects central carbon metabolism in host cells and links metabolic changes to disease severity.

bioRxiv · Feb 24, 2021Microbiology

Cytotoxic lymphocytes target HIV-1 Gag through granzyme M-mediated cleavage

E. Saccon, F. Mikaeloff, P. Figueras Ivern, A. Vegvari, A. Sonnerborg, U. Neogi, R. van Domselaar

This study shows that granzyme M from cytotoxic lymphocytes cleaves HIV-1 Gag, potentially controlling infection without killing infected cells.

bioRxiv · Feb 24, 2021Immunology

Type-I interferon signatures in SARS-CoV-2 infected Huh7 cells

X. Chen, E. Saccon, K. S. Appelberg, F. Mikaeloff, J. E. Rodriguez, B. S. Vinhas, T. Frisan, A. Vegvari, A. Mirazimi, U. Neogi, S. Gupta

This study identifies delayed and dysregulated type-I interferon signaling in SARS-CoV-2 infected Huh7 cells and shows that IFN-I pretreatment reduces susceptibility.

bioRxiv · Feb 4, 2021Microbiology

Pulmonary stromal expansion and intra-alveolar coagulation are primary causes of Covid-19 death

L. Szekely, B. Bozoky, M. Bendek, M. Ostad, P. Lavignasse, L. Haag, J. Wu, X. Jing, S. Gupta, E. Saccon, A. Sonnerborg, Y. Cao, M. Bjornstedt, A. Szakos

The paper presents autopsies of Covid-19 patients showing pulmonary stromal expansion and intra-alveolar coagulation as primary causes of death, with virus replication in pneumocytes and macrophages.

bioRxiv · Dec 23, 2020Pathology

Tropism of SARS-CoV-2 in commonly used laboratory cell lines and their proteomic landscape during infection

E. Saccon, X. Chen, F. Mikaeloff, J. E. Rodriguez, L. Szekely, B. S. Vinhas, S. Krishnan, S. Byrareddy, T. Frisan, A. Vegvari, A. Mirazimi, U. Neogi, S. Gupta

This study assesses SARS-CoV-2 tropism and proteomic changes in human cell lines, finding cell-type-specific susceptibility and interferon signaling dysregulation.

bioRxiv · Aug 28, 2020Microbiology